Peprazom Adult & adolescent (from 12 yr) Erosive reflux esophagitis 40 mg once daily for 4 wk.
Long-term management of patient w/ healed esophagitis to prevent relapse 20 mg once daily.
Symptomatic treatment of GERD 20 mg once daily in patient w/o esophagitis. Subsequently 20 mg once daily when needed.
Adult Treatment & prevention of H. pylori-associated ulcers Esomeprazole 20 mg w/ amoxicillin 1 g + clarithromycin 500 mg, all bid for 7 days.
Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily for 4-8 wk.
Prevention of gastric & duodenal ulcers associated w/ NSAID therapy in patient at risk 20 mg once daily.
Prevention of rebleeding of gastric & duodenal ulcers 40 mg once daily for 4 wk after IV-induced prevention of rebleeding of peptic ulcers.
Zollinger-Ellison syndrome Initially 40 mg bid. Max: 80-160 mg. Doses >80 mg daily should be divided & given bid.
Peprazom IV Adult Reflux esophagitis 40 mg once daily.
Reflux disease 20 mg once daily.
Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily.
Gastric & duodenal ulcers associated w/ NSAID therapy 20 mg once daily.
Prevention of rebleeding of gastric & duodenal ulcers 80 mg bolus infusion over 30 min followed by continuous IV infusion of 8 mg/hr over 72 hr.
Severe liver impairment in patient w/ GERD Max: 20 mg daily.
Severe liver impairment in patient w/ bleeding ulcers Initial bolus dose of 80 mg, followed by continuous IV infusion 4 mg/hr for 71.5 hr.
Childn 12-18 yr Erosive reflux esophagitis 40 mg once daily.
GERD 20 mg once daily.
1-11 yr <20 kg Erosive reflux esophagitis 10 mg once daily.
≥20 kg 10 mg or 20 mg once daily.
GERD 10 mg once daily.